Lee Responds to "Testing for Hardy-Weinberg Disequilibrium"

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Lee Responds to “Testing for Hardy-Weinberg Disequilibrium”

I appreciate Weinberg and Morris’ thoughtful commentary (1) on my paper (2). In their article, they put my work under the perspective of gene mapping in the postgenomic era. I share the same view with them that the method proposed in my paper amounts to a tree-shaking approach to harvesting the high-hanging fruit (a low-cost approach to generating hypotheses aimed at localizing diseasesusceptib...

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Hardy-Weinberg equilibrium (HWE) holds when, in a closed population with random mating and without mutation and natural selection, genotype frequencies at any locus is a simple function of allele frequencies. Testing for HWE is now a common practice in population genetics and genetic association studies of non-communicable diseases; however, it is less-regarded, or sometimes miss-interpreted, i...

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ژورنال

عنوان ژورنال: American Journal of Epidemiology

سال: 2003

ISSN: 0002-9262

DOI: 10.1093/aje/kwg152